1/13/2024 0 Comments Mn element toxicityRecent Findings: Common polymorphisms in the Mn transporter genes SLC30A10 and SLC39A8 seem to have a large impact on intracellular Mn levels and, in turn, neurotoxicity. In this review, we describe how underlying genetics may confer susceptibility to elevated Mn concentrations and how the epigenetic effects of Mn may explain the association between Mn exposure early in life and its toxic effects later in life. Mn appears to interfere with epigenetic processes, potentially leading to persistent changes in developmental programming, which warrants further study.Ībstract = "Purpose of Review: At elevated levels, the essential element manganese (Mn) is neurotoxic and increasing evidence indicates that environmental Mn exposure early in life negatively affects neurodevelopment. Summary: Genetics seems to play a major role in susceptibility to Mn toxicity and should therefore be considered in risk assessment. One human and two animal studies found persistent changes from in utero exposure to Mn but whether these changes have functional effects remains unknown. Recent studies on Mn and epigenetic mechanisms indicate that Mn-related changes in DNA methylation occur early in life. Genetic variation in iron regulatory genes may to lesser extent also influence Mn levels and toxicity. Purpose of Review: At elevated levels, the essential element manganese (Mn) is neurotoxic and increasing evidence indicates that environmental Mn exposure early in life negatively affects neurodevelopment.
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